Crossing Bridges between Extra- and Intra-Cellular Events in Thoracic Aortic Aneurysms
نویسندگان
چکیده
منابع مشابه
Crossing Bridges between Extra- and Intra-Cellular Events in Thoracic Aortic Aneurysms
Thoracic aortic aneurysms (TAAs) are common, life-threatening diseases and are a major cause of mortality and morbidity. Over the past decade, genetic approaches have revealed that 1) activation of the transforming growth factor beta (TGF-β) signaling, 2) alterations in the contractile apparatus of vascular smooth muscle cells (SMCs), and 3) defects in the extracellular matrix (ECM) were respon...
متن کاملThoracic Aortic Aneurysms
The true incidence and mortality rate of TAAs is not known. A population-based study reported an incidence of 5.9 new aneurysms per 100,000 person-years in a Midwestern community over a 30-year period with median ages of 65 years for men and 77 years for women. 51% of aneurysms were in the ascending aorta, 11% in the arch and 38% in the descending thoracic aorta. Prevalence may be at least 3-4 ...
متن کاملThoracic and abdominal aortic aneurysms.
Aneurysms of the aorta are at times evaluated and treated by physicians from a number of specialties. Indeed, whereas cardiac surgeons operate on the ascending aorta and arch and vascular surgeons manage abdominal aortic aneurysms, at present the responsibility often falls to cardiologists to oversee the medical care of patients with aortic disease of all types. However, although formally train...
متن کاملProteomic comparison between abdominal and thoracic aortic aneurysms.
The pathogenesis of abdominal aortic aneurysms (AAAs) and that of thoracic aortic aneurysms (TAAs) is distinct. In this study, to reveal the differences in their biochemical properties, we performed quantitative proteomic analysis of AAAs and TAAs compared with adjacent normal aorta (NA) tissues. The proteomic analysis revealed 176 non-redundant differentially expressed proteins in the AAAs and...
متن کاملAdventitial Fibroblast Abormality in Thoracic Aortic Aneurysms and Aortic Dissections
BACKGROUND Development of thoracic aortic aneurysms and aortic dissections (TAAD) is attributed to unbearable wall tension superimposed on defective aortic wall integrity and impaired aortic repair mechanisms. Central to this repair mechanisms are well-balanced and adequately functional cellular components of the aortic wall, including endothelial cells, smooth muscle cells (SMCs), inflammatory...
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ژورنال
عنوان ژورنال: Journal of Atherosclerosis and Thrombosis
سال: 2018
ISSN: 1340-3478,1880-3873
DOI: 10.5551/jat.rv17015